In this article you can read the instructions for use of the drug Utrozhestan. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Utrozhestan in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Utrozhestan in the presence of existing structural analogues. Use for the treatment of infertility, recurrent miscarriage, when planning pregnancy and menopause in women, including pregnancy and breastfeeding. Side effects and effects of taking the drug. Menstruation after taking the medicine.
Utrozhestan- progestational drug. Progesterone, the active substance of the drug Utrozhestan, is a hormone of the corpus luteum. By binding to receptors on the surface of cells of target organs, it penetrates into the nucleus, where, activating DNA, it stimulates RNA synthesis.
Promotes the transition of the uterine mucosa from the proliferation phase caused by follicular hormone to the secretory phase. After fertilization, it promotes the transition to the state necessary for the development of a fertilized egg. Reduces excitability and contractility of the uterine muscles and fallopian tubes, stimulates the development of the end elements of the mammary gland.
By stimulating protein lipase, it increases fat reserves and increases glucose utilization. By increasing the concentration of basal and stimulated insulin, it promotes the accumulation of glycogen in the liver and increases the production of gonadotropic hormones of the pituitary gland; reduces azotemia, increases nitrogen excretion in urine.
Activates the growth of the secretory section of the acini of the mammary glands, induces lactation.
Promotes the formation of normal endometrium.
Pharmacokinetics
When taken orally
Micronized progesterone is absorbed from the gastrointestinal tract. It is excreted in the urine in the form of metabolites, 95% of which are glucurone-conjugated metabolites, mainly 3-alpha, 5-beta-pregnanediol (pregnandione).
These metabolites, which are determined in blood plasma and urine, are similar to substances formed during the physiological secretion of the corpus luteum.
For vaginal insertion
Absorption occurs quickly, progesterone accumulates in the uterus. High level progesterone is observed 1 hour after administration. When administered in doses of more than 200 mg per day, the concentration of progesterone corresponds to the 1st trimester of pregnancy. It is excreted in the urine in the form of metabolites, the main part being 3-alpha, 5-beta-pregnanediol (pregnandione).
Indications
Progesterone deficiency conditions in women, including:
for oral administration
- premenstrual tension syndrome;
- violations menstrual cycle due to ovulation or anovulation disorders;
- fibrocystic mastopathy;
- premenopause;
- hormone replacement therapy for menopause (in combination with estrogen drugs).
for vaginal insertion
- hormone replacement therapy for progesterone deficiency with non-functioning (absent) ovaries (with egg donation);
- luteal phase support during preparation for in vitro fertilization;
- luteal phase support in spontaneous or induced menstrual cycle;
- premature menopause;
- hormone replacement therapy (in combination with estrogen drugs);
- infertility due to luteal insufficiency;
- prevention of habitual or threatened abortion due to progestin deficiency;
- prevention of uterine fibroids;
- prevention of endometriosis.
Release forms
Capsules 100 mg and 200 mg.
There is no form of administration in the form of tablets or suppositories, only in the form of capsules. Everything else does not apply to the original drug Utrozhestan. Capsules of the drug can be administered intravaginally, which is an analogue of the suppository form.
Instructions for use and dosage regimen
The duration of therapy is determined individually, depending on the clinical situation.
For oral administration
The drug should be taken orally with water. In most cases, with progesterone deficiency, the daily dose of Utrozhestan is 200-300 mg, divided into 2 doses (morning and evening).
In case of luteal phase insufficiency (premenstrual tension syndrome, menstrual irregularities, fibrocystic mastopathy, dysmenorrhea, premenopause), the daily dose of the drug is 200 or 400 mg for 10 days (usually from the 17th to the 26th day of the cycle).
For hormone replacement therapy in peri- and postmenopause while taking estrogen, Utrozhestan is used at a dose of 200 mg per day for 10-12 days.
For intravaginal administration
At complete absence progesterone in women with non-functioning (absent) ovaries (egg donation), the drug is administered intravaginally against the background of estrogen therapy, 200 mg per day on the 13th and 14th days of the cycle, then 100 mg 2 times a day from the 15th to On the 25th day of the cycle, from the 26th day and if pregnancy is detected, the dose increases by 100 mg per day every week, reaching a maximum (600 mg per day), divided into 3 administrations. This dose is usually used for 60 days.
To maintain the luteal phase during an in vitro fertilization cycle, it is recommended to administer intravaginally from 200 to 600 mg per day, starting from the day of injection of human chorionic gonadotropin during the 1st and 2nd trimesters of pregnancy.
To maintain the luteal phase in a spontaneous or induced menstrual cycle, in case of infertility associated with dysfunction of the corpus luteum, it is recommended to administer intravaginally 200-300 mg per day, starting from the 17th day of the cycle for 10 days, in case of delayed menstruation and diagnosis pregnancy treatment should be continued.
In cases of threatened abortion or in order to prevent habitual abortions that occur against the background of progesterone deficiency, 200-400 mg is prescribed intravaginally daily in 2 doses (morning and evening) in the 1st and 2nd trimesters of pregnancy. Capsules are inserted deep into the vagina.
Side effect
- allergic reactions;
- drowsiness;
- transient dizziness (1-3 hours after taking the drug);
- intermenstrual bleeding.
Contraindications
- tendency to thrombosis;
- acute phlebitis or thromboembolism;
- bleeding of unknown etiology from the genital tract;
- incomplete abortion;
- porphyria;
- established or suspected malignant neoplasms of the mammary glands and genital organs;
- severe liver dysfunction (for oral administration);
- hypersensitivity to the components of the drug, incl. to peanut butter, soy.
Use during pregnancy and breastfeeding
Utrozhestan is indicated for use in the 1st and 2nd trimesters of pregnancy.
Use with caution during pregnancy (due to the risk of liver dysfunction) and during lactation.
special instructions
Utrozhestan should not be used for contraception.
Impact on the ability to drive vehicles and operate machinery
When taking the drug orally, caution should be exercised when engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions.
Drug interactions
When used together, Utrozhestan enhances the effect of diuretics, antihypertensive medicines, immunosuppressants, anticoagulants.
Reduces the lactogenic effect of oxytocin.
Analogues of the drug Utrozhestan
Structural analogues of the active substance:
- Iprozhin;
- Crinon;
- Prajeesan;
- Progesterone;
- Progestogel;
- Utrozhestan.
If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.
There's nothing worse for a woman than losing her unborn child, but that's already enough developed child. But miscarriages are a fairly common occurrence, both in the first weeks of pregnancy and in the 3rd trimester. One of the reasons for this situation is a lack of progesterone. This hormone is necessary to maintain the good condition of both the fetus and the mother. It is produced throughout pregnancy in increased quantities, but sometimes this is not enough. In this case, doctors prescribe Utrozhestan to their patients during pregnancy.
Progesterone is produced first in the ovaries, then in the placenta itself. It must be present in a woman’s body in order to conceive a child. If it is not enough, the uterus will not be able to accommodate the fetus; it will reject it at the stage of a fertilized egg. The same thing will happen if there is not enough progesterone at some stage of pregnancy. This is why a progesterone analogue, for example Utrozhestan, is so necessary.
No one doubts its benefits: when a child is in danger, there is no time to think about possible minor side effects. However, does Utrozhestan really save the baby’s life? And how does it actually work? To understand the risk you are taking by taking this medicine during pregnancy, you need to understand what kind of drug it is.
Compound
Utrozhestan is a synthetic analogue of the hormone progesterone. Unfortunately, it is not easy to compensate for the deficiency of this hormone during pregnancy, since it is not directly perceived by the body from the outside and is not digested in the stomach. But scientists solved this problem by creating micronized progesterone - these are hormone molecules surrounded peanut butter. This makes it easier to digest and is not rejected by the body.
The composition of the medicine includes:
- Progesterone (micronized or natural)
- Peanut butter
- Soy lecithin
- Gelatin
- Glycerol
Since there are no substances that can react negatively with other medications, Utrozhestan during pregnancy can be safely taken in combination with any drug that your doctor prescribes.
Impact at various stages
Lack and excess of progesterone on different stages pregnancy threatens a woman with different consequences. Therefore, taking medicine in the 1st trimester or in the 3rd are completely different things.
In the 1st trimester of pregnancy, unlike the 3rd, uterine activity is not so dangerous, because it cannot cause premature birth. It is much more dangerous that the egg, and then the small fetus, will simply be rejected by the body. In addition, it is at this time that a redistribution of functions occurs between the ovary and the placenta. And any violation at this stage is dangerous. Therefore, doctors confidently prescribe Utrozhestan to their patients.
For the same reasons, it is safe to take the drug in the 2nd trimester of pregnancy, but it is better not to do so in the 3rd trimester. Hormone deficiency is not so dangerous. It cannot cause miscarriage or premature birth. But taking a medicine that affects hormonal background, can lead to disastrous results. In the 3rd trimester, excess progesterone is much more dangerous and less predictable than a deficiency. And controlling progesterone levels when taking Utrozhestan is not easy.
Action
Utrozhestan, entering the body, does not replace progesterone, but only supplements its volume. But in addition, it stimulates protein lipase and increases fat reserves. But not the fat that all girls are afraid of, but the fat that is a reserve of energy and strength during pregnancy.
The drug increases glucose utilization, promotes lactation, and activates the activity of the mammary glands, which is especially useful in the 3rd trimester. Utrozhestan also relaxes the nervous system, allowing the body to relax and unwind.
Advantages over other drugs
Unlike many drugs, Utrozhestan does not affect weight during pregnancy. After taking it, swelling and puffiness do not appear.
Contrary to popular belief, not all medications enter the child's body. Even in the 3rd trimester, this progesterone analogue does not reach the fetus. Therefore, you don’t have to worry that it will harm the baby.
Utrozhestan relaxes the uterus, reducing uterine activity. This way the uterus can adapt to the fetus without rejecting it.
Contraindications
Although the drug does not contain many components, it is still a medicine. And it has contraindications:
- Thrombosis and thrombophlebitis.
- Previous malignant tumors or diseases of the genital organs, mammary glands and uterus.
- Unusual bleeding or discharge from the genitals.
- Liver dysfunction, liver failure.
- Varicose and cardiovascular diseases.
- Diabetes.
- Bronchial asthma.
- Diseases, past or ongoing, of the central nervous system.
Be careful. Your doctor should monitor you while you take the drug. Especially in the 3rd trimester, when any changes can cause premature birth. Visit your doctor as often as possible to help predict problems before they occur.
Side effects
Serious straight side effects the drug does not. The main ones are drowsiness, absent-mindedness, dizziness. Therefore, try not to take Utrozhestan before leaving home, at work or in transport.
Another side effect is liver disease. They develop if you take Utrozhestan in the 3rd trimester during pregnancy.
The most dangerous thing when taking the drug is excess progesterone. The consequence of this may be indigestion. Then the baby will not receive enough energy and will not be able to grow well. As a result, he may be underdeveloped if this happened in the 1st trimester, or be born weakened if in the 3rd.
Application
You can take Utrozhestan in 2 ways:
- In the form of capsules by mouth
- In the form of suppositories by insertion into the vagina
The second method is the safest and most effective, as it reduces the likelihood of side effects. Of course, in the 3rd trimester, when the stomach is in the way, it is much more convenient to use pills, however digestive system may not respond well to the drug.
Sometimes a woman cannot get pregnant or carry a child to term. The cause of infertility and miscarriages often lies in hormonal imbalance - insufficient production of progesterone.
In this case, the salvation may be the prescription of Utrozhestan, a drug that can bring the hormonal balance to normal.
The ovaries produce a special hormone that is necessary for pregnancy to occur. normal development and preservation of the fetus, as well as the correct course of labor.
If the hormone is produced in insufficient quantities, therapy using hormonal agents is prescribed.
Utrozhestan is a plant analogue of the enzyme produced by the corpus luteum.
The formula of the product is completely identical to progesterone molecules. Therefore, the drug has the same effect on a woman’s body as a natural hormone.
Indications:
- fibrocystic mastopathy;
- violation or lack of production;
- the need for hormone replacement therapy - used during menopause, egg donation, if an enzyme deficiency is detected;
- support of the progesterone phase - in case of an induced or spontaneous cycle, before IVF, in case of infertility;
- preventive treatment - associated with insufficient production of progesterone, with the risk of developing endometriosis, as well as fibroids.
The regimen and duration of taking the hormone, the recommended dosage depend largely on general condition patients.
So, the duration of oral or intravaginal administration is:
- fibrocystic mastopathy, hormone replacement therapy, dysmenorrhea - 10-12 days;
- egg donation, lack of progesterone as a result of non-functioning ovaries - 2 months;
- support of the progesterone phase during IVF - according to individual indications, the course of treatment can last for the entire period of pregnancy.
A plant hormone can be prescribed simultaneously with sedatives or antispasmodics. It is not recommended to use Utrozhestan on your own.
Most often, Utrozhestan is prescribed if there is no pregnancy for a long time, which is associated with hormonal imbalance.
Signs of insufficient progesterone production may include uterine hyperplasia, menstrual irregularities, and the appearance of cystic formations.
Introducing an additional dose of the hormone into the body eliminates the problem and helps conception. The Utrozhestan treatment regimen is developed individually .
But the instructions for the drug mention that the average dosage is in the range of 200-400 mg per day. The doctor may stop the drug if pregnancy occurs. The dose reduction should occur gradually, every 3 days the dose is reduced by 50 mg.
In case of infertility caused by impaired functionality and formation of the corpus luteum, intravaginal administration of the drug is recommended.
Capsules are administered from the 17th day of the cycle. Course duration is 10 days. Even if pregnancy is detected against the background of Utrozhestan, treatment should continue.
The drug activates the production of secretory endometrium, stimulates the uterine mucosa to enter the secretory phase and prepares the organ for egg implantation.
Thanks to the drug, excitability and contractile activity muscle tissue of the uterus.
Need for use during pregnancy
As the embryo develops, the placenta takes over the function of producing progesterone. A lack of the enzyme leads to the threat of miscarriage.
In this case, the woman feels pain in the pelvic area and lower back. Present in the discharge. Utrozhestan on early stages pregnancy is prescribed for the purpose of preserving the fetus.
Even if before conception the ovaries coped with the production of the enzyme, in case of threat of miscarriage, hormone replacement therapy is recommended.
The advantage of Utrozhestan is that the drug can be administered intravaginally. Therefore, the course of treatment will be effective even with severe toxicosis.
Utrozhestan is often prescribed during pregnancy for preventive purposes, if up to this point the woman has already had several miscarriages or was accompanied by a previous pregnancy.
If there is a threat of miscarriage, Utrozhestan should be taken throughout the first trimester of pregnancy.
In case of isthmic-cervical insufficiency, the course can last up to 20 weeks.
During pregnancy, you should drink Utrozhestan 2-3 capsules per day, containing 200 g of the active substance. That is maximum dose plant progesterone is 600 mg per day.
If therapy is ineffective, the daily amount of Utrozhestan can be increased to 800 mg.
Sometimes Utrozhestan in suppositories is prescribed in the 2-3 trimester of pregnancy as part of complex therapy to reduce uterine tone. On later During pregnancy, the drug is administered intravaginally once a day at night. Can be used up to 34-36 weeks.
Utrozhestan suppositories prescribed during pregnancy are rapidly absorbed, ensuring a constant concentration of the enzyme in the plasma. However, women themselves sometimes refuse treatment, citing the inconvenience of administering capsules.
Discontinuation of the drug most often occurs after the 12th week and is carried out gradually.
You can cancel Utrozhestan during pregnancy according to the following scheme: take 200 mg at night for a week, then take 100 mg once a day for a week, and 100 mg every other day for another 7 days.
Side effects of Utrozhestan include drowsiness, dizziness, and allergies.
In addition, many pregnant women note an increase light discharge, after administering Utrozhestan vaginally. or, odorless, similar to.
Also, intravaginal administration can cause a burning sensation in the vaginal area. A similar symptom may be a sign of vaginitis.
Such symptoms should be reported to the gynecologist. In this case, it is necessary to reduce the dosage of the drug or replace it with an analogue.
Release form
Utrozhestan tablets are produced in the form of soft round-shaped capsules with a yellowish tint.
Each capsule contains an oily liquid of uniform consistency. One capsule may contain 100 or 200 mg of the substance.
Gelatin, glycerol, soy lecithin, as well as titanium dioxide and peanut oil are used as auxiliary components.
Capsules are packaged in blisters, each of which can contain 7 or 15 capsules. The cardboard package contains 2 blisters. On the recommendation of a doctor, take the capsules orally with water, or insert them into the vaginal area.
When taken orally, an increase in enzyme concentration is observed within 1 hour. The maximum level is detected within 1-3 hours.
When introduced into the vaginal area, absorption of the drug occurs gradually.
The maximum concentration is reached after 2-6 hours. The required level of progesterone is maintained throughout the day with twice the use of capsules with a dosage of 100 mg.
Administration in an amount of 200 mg per day corresponds to the level of progesterone with normal course 1st trimester. As with oral administration, it is excreted from the body in the urine.
Price
For whom the drug is contraindicated
It is not recommended to take Utrozhestan if a woman has acute thrombophlebitis or an increased tendency to thrombosis.
Contraindications also include: hypersensitivity to ingredients, with an unidentified cause, oncology of the reproductive system, porphyria, liver disease, incomplete abortion.
For liver diseases, Utrozhestan can be used intravaginally. When feeding a baby, the drug is taken only as prescribed by a doctor.
Analogs
If for some reason the use of Utrozhestan is impossible, the drug is replaced with structural analogues:
- Iprozhin - available in capsules containing 100 mg of active substance;
- Crinone - available in gel form, in 1 applicator the active substance content is 90 mg;
- Prajisan - capsules containing 100 mg of enzyme;
- Progestogel - gel in tubes of 80 g, the tube contains 800 mg of progesterone;
- Progesterone - in the form of a solution for injection, ampoules of 1 and 2.5%.
- - coated tablets containing 10 mg progesterone.
Unlike most analogues, Utrozhestan can be used in a way that is convenient for the woman herself. In addition, the drug is produced from plant materials, which significantly increases its safety and absorption.
Utrozhestan is medicinal product, which is based on hormone progesterone. It should be noted that a certain amount of this substance is needed for an adequate pregnancy.
That is why Utrozhestan actively uses the obstetrics and gynecology sector.
In order to understand how the drug works, you need to understand how it affects the body. expectant mother natural progesterone.
Why is Utrozhestan prescribed to those who are planning a pregnancy?
In a woman’s body, the hormone we are talking about is synthesized by several organs. This connection is often defined as pregnancy hormone, since its normal level of progesterone indicates that ovulation is effective. Otherwise, fertilization simply cannot occur.
In pregnant women, the level of this hormone in the blood increases significantly. The reason for this is the functioning of the placenta. Exactly normal amount progesterone is one of the the most important factors have a good pregnancy.
Progesterone begins to have a pronounced effect already when the inner lining of the uterus prepares to secure the egg after the latter has been fertilized. Progesterone stops acting only at the very end of pregnancy before the expected date of birth of the baby.
Utrozhestan candles, in fact, have only one indication - lack of progesterone in the female body. But different expressions of this are possible: cyst, endometrium, as well as hyperandrogenism, manifested by skin rashes and active hair growth, which is not typical for a woman in a normal state.
For those who want to become parents in the near future, the drug Utrozhestan can be prescribed in three situations:
- Decreased progesterone in the blood, why not? special symptoms. This phenomenon is not so rare, and it is dangerous both when pregnancy has occurred and at the time of planning it, since the likelihood of conception is significantly reduced. Further use of the drug is possible after pregnancy, if there is a risk of early miscarriage or premature birth. Utrozhestan is often used in the first few weeks of pregnancy.
- Infertility caused by a lack of progesterone.
- Miscarriage resulting from hormonal imbalance, expressed in a decrease in the amount of progesterone specifically.
To understand that the use of the drug is really necessary, you need to conduct a study in the laboratory. It is important to take into account day of the menstrual cycle, since progesterone tests are usually recommended to be carried out in the second part of the cycle.
Utrozhestan can completely replace natural progesterone, since it has a completely similar molecular structure. The difference from the hormone itself is that the medication is entirely, one hundred percent, absorbed by the intestines.
Utrozhestan is the only one existing on this moment analogue of the hormone progesterone of plant origin. Therefore, in comparison with chemically synthesized hormone analogues, it has fewer side effects, and the risk of them is also lower. The fact that the progesterone molecules in Utrozhestan are surrounded by peanut butter helps improve the absorption of the drug in the digestive tract.
The drug helps prepare female body
to pregnancy, as it helps ensure the growth of the endometrium. In fact, it affects the body in the same way as progesterone itself. The endometrium swells, it receives a loosened structure, which helps the egg implant after fertilization and attach to the wall of the uterus.
At the same time, the drug prevents an increase in estrogen in the second phase of the cycle. It can increase body temperature and provide nervous relaxation. That is, the body thanks to Utrozhestan preparing for conception, since it has all the functions of natural hubbub, and the correct prerequisites are created in the body, both for the onset of pregnancy and its correct course in the first half.
Utrozhestan reduces the tone of the uterus. This makes it possible to provide harmonious development fetus in the first weeks of variability. The risk of miscarriage also becomes lower. When taking Utrozhestan, women do not have to worry about gaining weight, since the drug is not able to retain fluid in the body and take part in fat and carbohydrate metabolic processes.
So, we can safely say – very a worthy analogue of natural progesterone. And women whose hormonal balance is disturbed for one reason or another have a high chance of becoming pregnant, carrying and giving birth healthy baby.
Utrozhestan during pregnancy
Cases of miscarriages are now not so rare, which is facilitated by modern ecological problems, mistakes in the lifestyle of pregnant women, from bad habits. Sometimes the reasons may concern a specific woman, sometimes they are global. Negative influence have stress, conflicts, all kinds of infections - all this can have an extremely negative impact on how the pregnancy proceeds.
Another very negative factor which belongs to the narrower ones is lack of progesterone in the body. In the body of a pregnant woman, this hormone is also produced by the placenta. But in some cases, the expectant mother’s body may experience disruptions in the production of progesterone and a decrease in the quality of the hormone.
This most often occurs during the most unsafe period of pregnancy - 8-12 weeks. Then the risk of miscarriage increases significantly. But this is not a reason to despair, since modern medicine, thanks to such natural progesterone substitutes as Utrozhestan, helps to qualitatively solve the problem hormonal imbalances.
For pregnant women, vaginal use of Utrozhestan (in the form of suppositories) is recommended more often than tablets, since the substance is absorbed extremely quickly, without reaching the uterus. Therefore, suppositories are better tolerated by expectant mothers. The use of the drug is not dangerous for the expectant mother.
It does not replace natural hormones, but only increases their quantity. The medicine works on improvement of the inner layer of the uterus, known as the endometrium. It affects the uterus and its tubes, reduces the level of contractility and excitability of their muscles.
The drug can be combined normally with antispasmodics and sedatives. His final goal is to help the expectant mother give birth to a healthy baby on time, since there is also no danger for the child himself.
Additional benefits for the expectant mother are that Utrozhestan does not increase weight, does not cause swelling and does not affect indicators blood pressure. However, since the drug is hormonal, it is not without contraindications.
Thus, it must be taken into account that the drug cannot be prescribed to those pregnant women who have a tendency to thrombosis or thrombophlebitis. Among the obvious contraindications a diseased liver and previous malignant tumors are highlighted. For a number of other problems, such as diabetes, asthma, nervous system problems, the specialist must be extremely careful when prescribing this medication to you
There is also a danger in taking the drug for all nine months. The fact is that it can accumulate in the liver and negatively affect its functioning. Because of this, taking Utrozhestan is usually canceled on last trimester baby's expectations.
Instructions for use
There are two forms of the drug - capsules and vaginal suppositories. When planning conception, the dose of the drug in capsule form is usually 200-300 mg. The volume should be divided into two and consumed in the morning and evening.
Capsules are mainly used on days 16-25 of the cycle for a course of 10-12 days. Capsules are taken orally, not chewed and washed down with water. The dosage will be similar if Utrozhestan is prescribed for infertility, which is caused by a lack of progesterone in a woman.
Candles Utrozhestan absorbed faster into the blood, and they have less side effects, so they are often indicated for use. They need to be entered in supine position, experts generally recommend doing this before bed. The suppositories, after they have been introduced, dissolve slowly.
The maximum level of the hormone in the blood is reached at least 2 hours after direct administration. When you use suppositories twice a day, they last throughout the day. After administration, progesterone begins to quickly accumulate in the uterus, the inner lining of which begins to work normally.
If a woman manages to become pregnant, it is progesterone that maintains the most comfortable characteristics of the inner uterine lining for the baby. It is important to insert suppositories into the vagina as deep as possible. Using an applicator will make this process easier.
The duration of use of the drug is regulated by the doctor. In most cases, pregnant women are prescribed Utrozhestan for the first three months. In certain situations, treatment must be extended to twenty weeks. Everything here is determined by the presence or absence of various problems in the process of bearing a baby.
Despite the fact that Utrozhestan is not prohibited for pregnant women, in the third trimester it is prescribed with caution and only in special cases, since there is a risk of further problems in the liver.
Contraindications and possible side effects
A woman who wants to become a mother must understand that, despite the fact that in many cases Utrozhestan is the very saving Magic wand, the use of this drug is only permitted after appointing a specialist.
Only he can identify those factors due to which a hormonal drug may be prohibited for use. Moreover, in this case, it makes no difference what exactly we are talking about - Utrozhestan in tablets or a form of the drug such as suppositories.
Contraindications to taking Utrozhestan may be as follows:
- noticeable and complicated course varicose veins veins;
- presence of thrombophlebitis;
- liver diseases;
- certain types of tumors.
Some states are considered undesirable. So, caution is needed when diabetes mellitus, bronchial asthma, problems with the heart, blood vessels.
Side effects Utrozhestan theoretically has them, but they are rather an exception, since this happens very rarely. So, some women notice drowsiness and dizziness when taking Utrozhestan in tablet form, and they are expressed very slightly.
But do not forget about this if you are planning to drive a car, since even a minimal slowdown in the reactions of the central nervous system can affect the control of the car.
Price
Cost of the drug depends on the pharmacy where you buy it and the city where this pharmacy is located. So, 28 capsules of Utrozhestan 100 mg will cost from 370 to 445 rubles. And 14 capsules of the drug 200 mg cost between 369-420 rubles.
Analogs
According to the active substance, Utrozhestan has several analogues: Progesterone, Progestogel, Iprozhin, Duphaston. Moreover, the choice is often between Utrozhestan and Duphaston. Women are interested in how interchangeable they are and which one is better. The following differences can be identified between these drugs:
- Utrozhestan contains a natural micronized hormone progesterone. Duphaston includes its analogue.
- Duphaston has its advantages. Thus, the drug cannot cause allergic reactions and hormonal disorders. He has no negative effects in the form of dizziness, fatigue and constant drowsiness. Because of this, it does not in any way affect driving skills or the ability to perform actions that require quick reaction.
- Duphaston is available only in tablet form, and Utrozhestan can be used both orally and as suppositories.
- When it comes to choosing a drug for nursing woman, then preference is given to Duphaston, since it cannot be excreted in mother's milk.
The choice of a specific medication will be made solely by the doctor. In each individual case, this solution may be different. Possible contraindications and existing symptoms are taken into account. If your doctor has prescribed Utrozhestan to you, you should not take another drug instead, as the result may be completely different. Utrozhestan itself is considered safe and effective, which is confirmed by a number of positive reviews.
Utrozhestan candles: reviews
The effectiveness of the drug has been confirmed numerous reviews women who, thanks to him, were able to realize their long-awaited dream of motherhood.
Anna, Ekaterinburg: I was diagnosed with insufficiency of the second phase of the cycle, which is why ovulation did not occur. After taking the tests, it became clear that there was not enough progesterone in the body. The doctor recommended Utrozhestan, and already in the first cycle I was able to get pregnant!
Marina, Moscow: Not long ago I had a miscarriage, and because of this, the doctor prescribed Utrozhestan. AND pregnancy came very quickly. It turned out that the cause of the previous miscarriage was a lack of progesterone. Utrozhestan helped me become a mother this time.
Katerina, Tula:
They recommended Utrozhestan in the center where I was being observed at that time. I noticed that sometimes I feel dizzy. I still don’t understand whether it was a side effect of the drug or the result of excitement that everything could happen soon. The doctors advised me to do a test later, and it was positive! Nine months later, such a long-awaited daughter was born.
In addition to patient reviews, you should also read reviews from experts, that is, doctors who prescribe this drug. Below are some of them:
Irina Mikhailovna: Utrozhestan – a drug high efficiency , which I prescribe to those who are planning to conceive a child, relatively often. Those who used it under my guidance were able to prevent the development of numerous side effects. It is important to understand that the drug is hormonal, and accordingly, it has certain connection with the functioning of the kidneys and liver. Therefore, I believe that women should not use it during pregnancy.
Victor Petrovich:
Utrozhestan in tablets and suppositories helps make up for a natural deficiency progesterone, and the chances of getting pregnant due to this increase. During my practice, I observed some side effects in patients when using the drug. So, it is possible that sweating, fever, and toxicosis may increase during further pregnancy. But this does not reduce the effectiveness of the drug. The extent to which it is advisable to prescribe it is determined by the general clinical picture and in each case is decided individually.
Vladimir Alekseevich: During medical practice I came across cases when it was Utrozhestan that became salvation and allowed a woman finally get pregnant. And sometimes it became the reason for the appearance of very unpleasant symptoms. Each situation is individual. I will never give a patient an appointment without conducting a detailed examination of her. It is very important to strictly follow the doctor’s instructions and the prescribed regimen for using the drug. Only thanks to a very responsible approach to this hormonal agents you can reduce the risk of side effects.
Thus, Utrozhestan - great opportunity for those who have not yet experienced the joy of motherhood due to problems with progesterone. Only a doctor can prescribe it and, when using it, be sure to follow all his recommendations.
Utrozhestan belongs to the group of drugs that are sources of the female hormone progesterone. His task is to help the woman bear the baby. However, it is prescribed not only to those who are at risk of miscarriage.
Utrozhestan during pregnancy
Modern gynecologists are very fond of prescribing this drug or its analogues. Poor ecology and the frantic pace of life weaken us, and even the most, at first glance, healthy women There are situations when you need to support the body hormonally. Progesterone drugs help a pregnant woman spend months waiting for her baby without unnecessary risks.
Release form, composition, mechanism of action
Utrozhestan is available in the form of capsules; depending on the dosage, they can be round (100 mg) or oval (200 mg). The capsules are soft to the touch, because... They have a gelatinous shell, and inside them there is a liquid substance. They can be either drunk or inserted into the vagina using the principle of suppositories.
Active ingredient: progesterone. Usually a hormone of plant origin is used, a complete analogue of the female sex hormone. Once in the blood, it binds to receptors on the surface of the “target” organs (uterus and ovaries) and penetrates the nuclei of their cells. It helps the uterus reach the state it needs for proper development fertilized egg. It becomes soft and does not contract, which allows the egg to attach firmly and receive nutrition. In addition, progesterone suppresses ovulation, promotes the development of mammary glands, and helps the expectant mother accumulate fat (yes, this is also intended by nature for the safe bearing of a baby).
At the pregnancy planning stage, Utrozhestan helps to form a thick mucous membrane (endometrium) on the uterus, which will allow the egg, if fertilized, to attach to the uterus and begin development.
Use in early and late pregnancy
Official instructions to the drug states that pregnant women need to take Utrozhestan in the first and second trimesters of pregnancy. This is due to the fact that progesterone deficiency can only occur when the placenta is not fully formed. At 16–20 weeks, the placenta is fully formed and provides the baby with hormones. Taking progesterone drugs after 20 weeks is considered pointless by many.
However, each case is individual, and there are women for whom doctors extend the drug to 34–35 weeks, mainly due to increased tone uterus.
An analysis of progesterone levels is done at the beginning of pregnancy - based on its results, a decision is made on prescribing the drug
The only question here is trust in the doctor. At one time I had to put Utrozhestan before 27 weeks. I believe that I would have used it until the very end if I had not raised the question of stopping taking it. The pregnancy proceeded calmly, and it seemed that there was no point in spending money on an expensive drug, which, moreover, had to be taken regularly, without missing a single capsule (this meant regular trips to the pharmacy and an endless search for discounts).
Objectively: there are other drugs, with a different mechanism of action, aimed at maintaining pregnancy in the third trimester, for example, Ginipral. It prevents excessive tone. However, the issue of stopping taking Utrozhestan or switching to other medications should be discussed only with your doctor! Utrozhestan does not have any effect on the fetus, so there is no need to be afraid to take it if the doctor insists on it and gives valuable arguments.
Indications, contraindications, side effects
Pregnant women are prescribed Utrozhestan for:
- threat of abortion or if the woman has had abortions before;
- the existing threat of premature birth (when the due date has not yet approached, and the cervix has begun to shorten);
- increased uterine tone.
My doctor prescribed this drug to me after an ultrasound at 7–8 weeks of pregnancy. The reason was the discovery of a cyst corpus luteum(Consequently, possible violation production of progesterone). In addition, the gynecologist drew attention to the insufficiently good attachment ovum to the walls of the uterus. The doctor immediately predicted that I would have to drink Utrozhestan until the middle of the second trimester. In addition to taking hormones, motor rest was prescribed at least until the first screening. 
To survive, the embryo must literally “grow” into the endometrium, and this requires progesterone
Women planning pregnancy and those diagnosed with infertility are prescribed Utrozhestan in preparation for the IVF procedure:
- to support the luteal phase (this helps the egg, if fertilized, to gain a foothold in the uterus);
- as hormone replacement therapy if the body does not produce enough progesterone.
In addition, Utrozhestan softens the onset of menopause and improves the quality of life of women who have had their ovaries removed for some reason.
Contraindications to the use of Utrozhestan are:
- thrombosis and thromboembolic disorders;
- bleeding from the vagina with an unknown cause;
- presence or suspicion of malignant tumors of the breast or genital organs;
- porphyria;
- incomplete abortion;
- liver diseases;
- age under 18 years (studies not conducted);
- breastfeeding (passes into breast milk);
- allergic reactions to the components of the drug (especially soy lecithin).
Like anyone hormonal drug, Utrozhestan has side effects. If the “side effects” make themselves felt too strongly, then you should talk to your doctor about reducing the dosage.
Women taking this drug may experience:
- drowsiness, dizziness;
- menstrual irregularities, spotting outside of menstruation;
- headache;
- nausea, bloating, constipation or diarrhea;
- skin rashes, itching.
If the side effects are too severe, your doctor may recommend switching from oral to intravaginal: as mentioned above, the capsules can be used in both ways.
Features of the use of hormonal drugs
If the doctor has prescribed you to take the drug once a day, then it is best to drink/put the capsule at night, because it can cause drowsiness. When taken orally, the capsule must be swallowed with plain water. When inserting into the vagina, you must wash your hands and insert the capsule as deeply as possible.
You should not take Utrozhestan with food: food will hinder the absorption of progesterone!
Only a doctor prescribes the dosage and regimen of the drug! Taking the drug in pregnant women and those who are just dreaming of conceiving a baby will differ greatly in the number of capsules per day and the duration of treatment. The manufacturer of the drug recommends taking 100–200 mg of the drug at a time and not going beyond daily norm at 600 mg.
Depending on the goals and condition of the woman, the doctor may prescribe a regimen of 2 or 3 doses per day. It is not necessary that the doses in the morning and evening will be equal: 200 mg at night and 100 mg in the morning are often prescribed to avoid weakness. The dose can also be maintenance, only 100 mg - it all depends on the diagnostic results. Therefore, first of all, you should focus on the doctor’s recommendations, because the annotation describes only general principles treatment.
The duration of the course will also be determined by the gynecologist. The official instructions prescribe the use of the drug until the end of the second trimester. For those planning a pregnancy, the course of treatment is usually shorter: it lasts 10 days, starting from the 17th day of the cycle.
Like any other hormonal drug, Utrozhestan must be taken strictly according to the schedule and preferably at the same time. It must be discontinued gradually: over the course of a week, the dosage is reduced by half (that is, the amount of the substance is reduced), then the same amount is taken once a day, then every other day, and then reduced to nothing. The doctor should also describe the withdrawal plan. 
A pill box or a special application on your phone will help you not to miss taking a capsule.
It is not advisable to skip taking pills. In my practice, there was a case when the pack ran out and a new one had not yet been purchased, and I had to skip the evening reception. There were no consequences from this, although unnecessary nerves were wasted. There are situations when the drug disappears from pharmacies due to supply interruptions. Considering all this, it makes sense to purchase Utrozhestan with a reserve: anyway, the drug is not abruptly canceled, which means it will most likely be used up.
The progesterone drug actively interacts with other medications. If a woman has to take other pills, she should definitely consult a doctor.
Photo gallery: which drugs cannot be combined with Utrozhestan
Tetracycline and penicillin antibiotics reduce the effectiveness of Utrozhestan Utrozhestan enhances the effect of drugs that lower blood pressure Utrozhestan enhances the effect of diuretics (diuretics) Utrozhestan may increase the need for insulin in patients with diabetes
Utrozhestan analogues - other progesterone-based products
Utrozhestan has analogues. It is interesting that among all these drugs there are no obviously cheap ones, that is, you will not be able to save significantly by taking an analogue. However, a substitute drug can help out if the main one is not on sale. Before taking an analogue, you should definitely consult a doctor!
Table: analogues of Utrozhestan and their features
| A drug | Release form | Compound | Peculiarities |
| Duphaston | Coated tablets, available in 20 or 28 pieces per package. | Dydrogesterone (progesterone analogue) 10 mg, excipients. | To maintain proper levels of progesterone, pregnant women are recommended to take 1 tablet 2 times a day, but the regimen is prescribed by a doctor in each specific case. The drug is in many ways similar to Utrozhestan. However, the manufacturer does not list drowsiness among the side effects, and also writes that “the drug does not affect the ability to drive vehicles or use other mechanisms.” For many women this can be important. |
| Prajeesan | Capsules, pack of 10 pieces. | Progesterone 200 mg, excipients. | As with Utrozhestan, this drug can be taken either orally or intravaginally. The manufacturer's recommended dosage for pregnant women is 200–400 mg 2 times a day. |
| Iprozhin | Capsules, pack of 15 or 30 pieces | Micronized progesterone 100 mg, excipients. | You can take it with water, or you can insert it into the vagina. To prevent miscarriage, a dose of 100–200 mg twice a day is recommended for pregnant women. The duration of treatment is determined by the doctor. |
| Crinon | Gel for intravaginal use. Each dose is packaged in a separate single-use vial. | Progesterone, 90 mg per dose, excipients. | Recommended for use when planning pregnancy. Pregnant women are allowed only if pregnancy occurred as a result of IVF and the gel has already been used in preparation for the procedure. In this case, it is used only at the earliest stages of waiting. |