Ginipral during pregnancy: reviews, instructions, dosage. Ginipral for uterine hypertonicity: use in the form of droppers and tablets

Despite the fact that many women prepare for conception in advance and under the supervision of doctors, the risks of complications always exist. The most common pathology is hypertonicity of the smooth muscles of the uterine walls. The condition is characterized by chaotic contraction of muscles that are in constant tension.
Hypertonicity is fraught with miscarriage and premature birth. Tense muscles of the uterus do not allow the developing fetus to be fully supplied with oxygen and nutrients. Prolonged hypoxia and starvation lead to pathologies in the development of the child.

Ginipral during pregnancy is an effective drug for relaxing the myometrial muscle tissue and reducing pressure in the uterine cavity.

The drug is available in tablet form and capsules for intravenous administration. The price of a blister (20 tablets) ranges from 170 to 200 rubles. A package for intravenous administration, consisting of 5 ampoules, costs 250–300 rubles.

The main active ingredient of Ginipral tablets is hescoprenaline sulfate.

Excipients: disodium edetate dihydrate, copovidone, magnesium stearate, lactose hydrate, corn starch and talc.

When taking Ginipral tablets during pregnancy, you must follow the instructions and recommendations of your doctor. If there is a threat of miscarriage, the drug is prescribed one tablet (500 mcg) with an interval of three hours, regardless of food intake.

After relief of the acute stage and stabilization of the condition, the time period is increased to 4–6 hours, gradually reducing the dosage (1–2 tablets per day).

Ginipral for intravenous administration is available in glass ampoules containing 2 ml of a ready-made solution containing 10 mcg of active substance. As auxiliary agents, the solution contains: 2H-sulfuric acid, sodium chloride, sodium pyrosulfate, deionized water.

The drug is administered by stream or drip intravenously in critical situations when there is a threat of termination of pregnancy. The contents of two ampoules are diluted in a 5% solution of glucose or sodium chloride. A few hours before the end of invasive therapy, the drug is prescribed in tablet form.

It must be remembered that the dosage of Ginipral during pregnancy is selected individually, after a thorough examination and study of the medical history.

When to stop Ginipral during pregnancy? A very important issue for the health of mother and baby. When using a high dosage, after achieving a therapeutic effect, the amount of the drug is reduced.

Abrupt withdrawal causes hypertonicity of the muscles of the uterine walls, which can lead to miscarriage or premature birth. To avoid negative consequences, discontinuation of Ginipral during pregnancy occurs in stages, the dosage of the drug is reduced, and the intervals between doses are increased.

Mechanism of action of the drug

Hexoprenaline is a tocolytic and selective beta2-agonist.

The tocolytic effect is manifested in relaxation of the blood vessels of the placenta and myometrium. Regular use of the drug prevents contraction of the walls of the uterus and eliminates its increased tone.

Under the influence of the drug, premature contractions stop, which allows you to bear a healthy child and prolong pregnancy until physiological birth.

Asparkam is often prescribed together with Ginipral. This is a time-tested drug for regulating metabolic processes, restoring electrolyte balance, and a source of magnesium and potassium. It is a physiological blocker of slow calcium channels.

Potassium and magnesium are necessary to maintain cardiac activity and have antiarrhythmic effects when taking Ginipral.

A lack of minerals leads to muscle excitability and increased muscle activity. Ginipral and Asparkam are an excellent combination during pregnancy and are prescribed for increased uterine tone.

Indications for use

Ginipral tablets during pregnancy and injections for intravenous administration are proven medications and are widely used in obstetric practice. Used when there is a threat of premature birth or miscarriage caused by various factors.

Indications for use are:

• the need for obstetric rotation of the fetus in transverse or oblique presentation;
• premature contractions;
• the need to relax the walls of the uterus before a cesarean section;
• pronounced contractile activity of the uterus.

The drug is actively used as an aid during labor to normalize the intensity of contractions.

Side effects

The side effects of Ginipral during pregnancy have been well studied and described by the medical community. If the drug is used for the first time, the woman should carefully monitor her well-being in order to take timely measures.

After taking the drug, the following phenomena may occur:

• nausea and dizziness;
• increased blood glucose levels;
• headache;
• a sharp drop in blood pressure;
• tremor of the limbs;
• increased sweating;
• cardiopalmus;
• swelling and diuresis (urinary retention).

Taking into account possible side effects, treatment is carried out under the supervision of a doctor with monitoring of blood pressure, cardiac activity and blood sugar. To eliminate tachycardia and heart pain, Finoptin is prescribed 30–60 minutes before taking the main drug.

If there is difficulty breathing and severe heart pain, the drug is discontinued. In most cases, Ginipral is tolerated without side effects or with minor discomfort, which can be easily corrected.

Contraindications

Only a doctor can decide how to use Ginipral during pregnancy. The drug is prescribed with caution for diabetes mellitus.

It is advisable to limit the consumption of table salt and liquid. Drinks containing caffeine may increase the side effects of the medicine.

During pregnancy, the hemodynamic parameters of the expectant mother and fetus are constantly monitored and the fetoplacental complex is assessed.

Absolute contraindications for taking Ginipral are:

• hypersensitivity to sulfites (especially in patients with allergies and bronchial asthma);
• cardiovascular diseases, including heart defects and coronary disease;
• kidney and liver diseases;
• first trimester of pregnancy;
• breast-feeding;
• thyrotoxicosis;
• sexual infections.

Interactions with other drugs and special instructions

It is important to remember that when exposed to calcium supplements, vitamin D and non-selective beta-blockers, the effect of Ginipral is neutralized.

During the period of use of the drug, constant monitoring of cardiac activity and blood pressure is recommended. In case of rupture of the amniotic membrane and dilation of the cervix by more than 2-3 cm, the chances of the effect of tocolytic therapy are negligible.

Analogs

Ginipral during pregnancy is an indispensable drug for preventing premature birth. Analogues are Ipradol and Partusisten. The drugs are similar in effect to Ginipral, but have fewer side effects.

Experience with the use of analogues shows that the drugs are effective and do not have a negative effect on the condition of the mother and newborn.

Prevention of uterine hypertonicity

With increased tension in the smooth muscles of the uterine walls, the expectant mother needs peace, a comfortable psychological environment and timely intake of medications that relieve spasms. For the entire period of treatment, a taboo is placed on sexual contact.

Most of the time the woman should be in a lying position. You can place a cushion under your feet, which will reduce abdominal tension.

It is important to start treatment for chronic diseases in a timely manner and avoid visiting crowded places, including work. Moderate walking in comfortable shoes without heels is recommended.

The expectant mother needs to include foods containing magnesium in her daily menu. The trace element helps reduce uterine hypertonicity and reduces the excitability of the nervous system. Magnesium is found in bran, buckwheat, oatmeal, legumes and greens.

To avoid complications, prepare for conceiving and carrying a child in advance. Treat your doctor’s recommendations with increased responsibility, follow your daily routine and maintain a positive psychological attitude.

It is important to remember that Ginipral is prescribed and taken only by the attending physician in a specialized clinic. Self-medication is unacceptable and can cause irreparable harm to the health of the mother and baby!

Useful video about increased uterine tone

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Few pregnancies go as normal, when nothing worries you, all tests and indicators are stable or do not cause concern. Increasingly, women are experiencing unexpected problems during pregnancy in different trimesters. If complications arise with pregnancy after 15 weeks, then Ginipral will help during pregnancy, serving as a guarantee that this difficult period in a woman’s life will end successfully and she will successfully give birth to a healthy child.

Ginipral during pregnancy - what is it prescribed for?

Many women are afraid to use hormonal medications while pregnant, thinking that it will harm them and the baby. However, Ginipral is a panacea for pregnant women if they want the pregnancy to go well and the baby to be born without serious pathological abnormalities. A huge threat to mother and baby is uterine agitation and hypertonicity, which, if nothing is done, leads to the uterus “pushing out” the fetus, contributing to miscarriages, spontaneous abortions and premature births.

What is the drug? Gynipral is a drug that affects a woman’s body at the cellular level, suppressing the activity of the stomata of cells located on the uterus and placenta. At the same time, the muscles of the uterus relax, blood and oxygen supply to the fetus are restored, and the threat of hypoxia of the embryo, which is fraught with the fading of its development, ceases. You must understand that the medication is effective only when the necessary cells have formed in the placenta and uterus; in the early stages of pregnancy it is not only useless, but also harmful. Ginipral is available in the following forms:

• tablet packages;
• liquid for intravenous administration;
• powder for the preparation of solution for injection.

Pills

If at the next examination the gynecologist discovered that a woman’s uterus is hypertonic during pregnancy, but she feels satisfactory, then she is prescribed Ginipral tablets, which can be taken on an outpatient basis during pregnancy, following the doctor’s instructions. One package contains 20 white round tablets, the active ingredient of which is hexoprenaline sulfate with a concentration of 1 tablet. 500 mcg. In addition to it, Ginipral tablets contain the following auxiliary components:

• corn starch;
• lactose, glucose;
• glycerol stearate, magnesium;
• disodium edetate dihydrate;
• talc.

Droppers

If, along with threateningly high hyperfunction of the uterus, pregnancy in the second and third trimesters is complicated by poor health, bleeding, and alcohol consumption, then the pregnant woman is immediately hospitalized. In the hospital, doctors prescribe Ginipral therapy, which may consist of a simultaneous single injection of a dose of the drug 5-10 mcg into a vein (1-2 ampoules), intravenous administration of a diluted Ginipral concentrate per 1 ampoule of 500 ml of sodium chloride. In addition to hexoprenaline, 1 ampoule of Ginipral contains the following components:

• sodium chlorine (saline solution);
• distilled water;
• Edetate disodium dihydrate.

Ginipral - instructions for use

Being a selectively acting ß-2-adrenergic agonist, it acts on the uterus during pregnancy, relaxing it and helping to eliminate contractions. The medicine is a hormonal drug that should not be used independently, without a prescription or indications from the treating gynecologist. In the early stages of pregnancy, Ginipral is useless because there are no cells in the uterus on which it could act. Ginipral is used in the following cases:

• in the second and third trimesters of pregnancy, when there is a significant threat to the life of the fetus from frequent and strong uterine contractions;
• during normal childbirth, when a woman is exhausted by frequent and ineffective uterine contractions with an undilated cervix, and she needs to rest a little;
• to stop labor pains if you need to urgently do a caesarean section.

Dosage

To urgently suppress uterine contractions during pregnancy, drip intravenous administration of Ginipral is used (per 1 ampoule of 500 ml sodium chloride) based on the following calculations:

• 1 ampoule is dripped at a rate of 2 drops per second;
• 2 ampoules – at a rate of 1 drop per second;
• 4 ampoules - at a speed of 1 drop in 2 seconds.

Ginipral droppers are placed in case of acute threat of pregnancy for two days in a row every 4 hours. If during this time the tone of the uterus has not returned to normal, then additional tablets are prescribed at the rate of 1 tablet every 3 hours for two days. For the next 2 days, take 1 Ginipral tablet every 4 hours. If the indicators have stabilized and the acute threat of miscarriage in late pregnancy has passed, then the number of tablets is reduced to 1 every 6 hours. After this, the course of treatment with the drug is determined by the attending physician depending on the condition of the pregnant woman.

Contraindications for Ginipral include the following ailments:

• complicated glaucoma;
• high blood sugar;
• Graves' disease;
• chronic ischemic diseases;
• infectious sexual diseases;
• individual intolerance, allergies.

Effect on the fetus

Women who are afraid that Ginipral will harm the fetus do not realize how serious the consequences of constant strong uterine contractions during pregnancy are. When the muscles of the uterus contract, nutrients and oxygen cease to flow to the embryo, it suffocates and may die. The effect of the drug before childbirth is enormous - by promoting relaxation of smooth muscles, it stimulates the supply of oxygen to the baby, saving him from hypoxia.

Those who during pregnancy followed all the doctor's recommendations regarding the complex course of Ginipral withdrawal - hormonal medications are withdrawn very slowly, carefully and gradually - gave birth to completely healthy babies, since Ginipral has no pathological effect on the intrauterine functional development of the fetus during pregnancy.

Side effects

Smooth muscle in the body is present not only in the placenta and uterus, so Ginipral has a lot of side effects. These include:

• From the side of the heart muscle - increased upper pressure, rapid heartbeat, uneven contraction of the ventricles, pain behind the sternum.
• From the gastrointestinal tract - sluggish peristalsis of the intestines, stomach, nausea, constipation, possible intestinal obstruction, renal dysfunction.
• From the side of the central nervous system - constant anxiety, sweating, sleep disturbances, trembling of fingers, dizziness, attacks of bronchial asthma.

Analogue

The main active component contained in Ginipral, hexoprenaline, is also found in other synonymous drugs, so they cannot be called analogues of this hormonal drug. An analogue of Ginipral is a medicine that acts similarly, but with a different active substance, for example, MgSO4 in 25% concentration, called “magnesia,” or suppositories with salbutamol.

Price for Ginipral

The drug cannot be classified as an expensive medicine, for which you may not have enough money during pregnancy. Its cost is quite affordable; the price range in Moscow can be seen in the following table.

Hypertonicity of the uterus, increased tone of the uterus... Probably every woman has heard these terms at least once during the entire period of pregnancy. In some cases, a gynecologist diagnoses a woman with a risk of premature birth and prescribes treatment. Often this is the drug GINIPRAL. This will be the subject of our conversation.

During pregnancy, the normal state of the uterine muscles is when they are completely relaxed: then we are talking about normotonus, i.e. normal degree of muscle tension. When the muscles are in an excited, contracted state, they say that the tone and, accordingly, the pressure in the uterine cavity increases.

If uterine hypertonicity is not treated, contractions may begin, which can lead to miscarriage or premature birth. To prevent this from happening, with increased uterine tone, medications are almost always prescribed to reduce its activity. In mild cases, this is a 25% solution of magnesium sulfate (“magnesia”), which is administered intramuscularly or intravenously, but if the increase in tone is significant, then a more serious drug is used - GINIPRAL. It is prescribed after 16 weeks of pregnancy - before this, hormonal drugs, which we discussed in previous issues, are usually used to treat the threat of miscarriage. The fact is that in the first trimester it is hormones that play a decisive role in the maintenance and development of pregnancy.

GINIPRAL is one of the drugs that affects the vessels of the uterus and placenta, as well as directly on muscle cells, including the uterus. Its effect is due to a decrease in the tone and amplitude of uterine contractions, general vascular resistance (vascular relaxation), and an increase in heart rate without a significant decrease in blood pressure. Under the influence of GINIPRAL, the blood supply to the uterus, fetus and placenta increases.

Due to its effect on the uterine receptors responsible for its contraction, GINIPRAL is most often used when there is a threat of premature birth (in the second and third trimesters of pregnancy), as well as during intrauterine hypoxia (oxygen deficiency) of the fetus, during childbirth (in case of disruption of labor) , to suppress uterine contractions before surgery.

GINIPRAL is used intravenously and orally (in tablets). A “loading” dose of 5-10 mcg is administered intravenously (in acute cases). For intravenous drip administration, dilute 50 mcg (contents of 2 ampoules of 25 mcg each) in 500 ml of 5% glucose solution. The tablets are started to be taken 2-3 hours before the end of the drip. Prescribe 1 tablet first, then after 3 hours, 1 tablet every 4-6 hours (total 4-8 tablets per day). If there is no need for intravenous administration of the drug, a quarter to a whole tablet is also prescribed every 4-6 hours.

According to the results of some studies, GINIPRAL is completely useless until the 26-27th week of pregnancy, since the receptors in the uterus through which this drug acts are formed only at this period. True, these data are not final, and the drug is still clinically effective at earlier stages, which allows its use to continue in accordance with the recommendations given much earlier.

Attention! If you suffer from bronchial asthma, have hyperthyroidism (increased thyroid function), heart rhythm disturbances, heart defects, liver and kidney diseases, glaucoma - tell your doctor immediately. After all, the presence of these diseases is a contraindication for the prescription of GINIPRAL and a reason to choose a different treatment.

The disadvantages of GINIPRALE include a decrease in the effectiveness of action after 48 hours and the presence of serious side effects in the mother. When this medicine is administered, as well as other drugs, a woman may experience palpitations, dizziness, a sharp decrease in blood pressure, heart rhythm disturbances, tremor (shaking of the hands), agitation, nausea, vomiting, headache, increased blood glucose and etc. That is why treatment is carried out under the control of blood pressure, heartbeat and blood sugar. To eliminate palpitations, along with GINIPRAL, a drug that eliminates this side effect is always prescribed, for example, 1 tablet of FINOPTINA 30 minutes before taking GINIPRAL. In most cases, this drug is still well tolerated, and these effects simply do not exist or are quite easily corrected.

Like any other drug, GINIPRAL should not be discontinued on your own, even if your stomach does not hurt and nothing seems to bother you. If you abruptly discontinue GINIPRAL, especially if you received significant doses - several tablets a day, the symptoms of a threatened miscarriage acutely reappear. GINIPRAL can be discontinued only under the supervision of a physician, gradually reducing the dose.

Increased uterine tone or the risk of premature birth are common pathologies for many pregnant women. To eliminate these threats to the successful bearing of a child, doctors often prescribe Ginipral during pregnancy. The effectiveness of the drug is so high that one intravenous injection can stop contractions. In this article, we will find out how safe Ginipral is for the fetus during pregnancy, as well as how and when it can be used.

Release form

The drug is commercially available in tablet form. One blister contains 10 tablets, one cardboard package contains two blisters. The tablets are convex, white, round in shape.

Ginipral is also available in the form of an injection solution. In this case, the drug is released in glass ampoules of 2 ml. One plastic package contains 5 ampoules. Pharmacies have cardboard boxes of one or five of these packages.

The mechanism of action of the drug Ginipral during pregnancy

The main active component of Ginipral is hexoprenaline hydrochloride. The substance administered intravenously reaches the tissues instantly; when taking the tablet form, this takes several hours. The drug is metabolized in the liver and kidneys, so excretion occurs along with urine and bile.

In the myometrium, heart, blood vessels and bronchi there are special groups of receptors that are affected by the active substance Ginipral. As a result, enzymes begin to be released that reduce the concentration of calcium in smooth muscle fibers, causing the muscle to stop contracting intensively. This has the following effects:

1. reduction or cessation of contractions;
2. relieving uterine hypertonicity;
3. increased heart rate;
4. improving blood supply to the placenta;
5. decreased blood pressure;
6. dilation of blood vessels;
7. weakening of intestinal motility;
8. decreased urine output.

Naturally, when a doctor prescribes Ginipral solution or tablets during pregnancy, he must take these effects into account. Therefore, control is established over the patient’s condition for the entire time the drug is taken. Due to the possibility of adverse reactions to the drug, the woman is observed either in a hospital or on an outpatient basis.

Indications for use of the drug Ginipral during pregnancy

This drug is a well-studied drug and is widely used in obstetric practice. Ginipral tablets or injections are recommended if there is a threat of miscarriage or premature birth, which can be triggered by various factors.

Ginipral during pregnancy is taken if the following symptoms are present:

• pronounced contractile activity of the uterus;
• placental insufficiency;
• premature contractions;
• transverse or oblique presentation of the fetus, requiring obstetric rotation;
• a condition of the uterus in which it is necessary to relax its walls in order to carry out.

Ginipral is often used as an aid during childbirth to normalize the intensity of contractions.

Side effects of the drug Ginipral during pregnancy

All possible side effects of the drug are known to the medical community. In order to take timely measures, a woman who takes Ginipral for the first time during pregnancy needs to monitor her well-being.

When using the drug, the following symptoms may occur:

1. headache;
2. trembling in the limbs;
3. increased heart rate;
4. increased blood glucose levels;
5. a sharp decrease in blood pressure;
6. nausea, dizziness;
7. decreased diuresis (urinary retention), swelling;
8. increased sweating.

Since side effects are likely, treatment is carried out only under the supervision of a doctor. At the same time, blood pressure, blood glucose levels, and cardiac monitoring are regularly measured. If the patient experiences tachycardia or heart pain, the doctor may prescribe Finoptin, which is taken half an hour to an hour before taking Ginipral.

If heart pain intensifies or breathing problems occur, the drug is discontinued. However, most often Ginipral is tolerated during pregnancy without any side effects or is accompanied by minimal discomfort, which is easy to eliminate.

Contraindications to the use of Ginipral

Only a doctor can decide how the patient should use the drug. Ginipral during pregnancy is prescribed with caution for diabetes mellitus.

During pregnancy, it is necessary to regularly monitor changes in hemodynamic parameters of the mother and fetus and evaluate the fetoplacental complex.

Ginipral during pregnancy is absolutely contraindicated in the following cases:

• diseases of the cardiovascular system (including coronary disease, heart disease);
• thyrotoxicosis;
• liver and kidney diseases;
• infections of the reproductive system;
• increased sensitivity to sulfites (in particular, in patients with allergies and bronchial asthma);
• first trimester of pregnancy;
• breast-feeding.

Precautionary measures

Ginipral during pregnancy is considered a fairly harmless drug, however, while taking it, it is still necessary to monitor the condition of the expectant mother and fetus. For this purpose, the following activities need to be carried out:

1. control of potassium levels in the blood;
2. blood test for glucose levels;
3. salt-restricted diet;
4. regular electrocardiography;
5. monitoring daily urine volume.

It is very important to perform fetal cardiotocography in a timely manner. During this study, a recording is made of the baby's pulse in the womb, which provides indirect information about his health.

Dosage of the drug Ginipral during pregnancy

There are several regimens for taking the drug, which differ depending on the purpose of the prescription. Below are the names and explanations of the schemes:

• Acute tocolysis. This is a one-time use of the drug, which is designed to quickly stop labor. It is used in case of fetal hypoxia (link) or the presence of any pathologies of the birth process. For this, one ampoule of the drug is used, which is administered intravenously or using a lineomat (a medical device that allows you to control the rate of administration of the solution). As soon as the intensity of contractions decreases, specialists can begin the necessary manipulations, for example, performing a caesarean section.
• Long-term tocolysis represents a long-term intravenous administration of the drug. Most often used as maintenance therapy after acute symptoms have resolved. Ginipral slowly enters the body through a dropper, while the rate of administration and duration of therapy depend on the individual indications of the patient.
• Massive tocolysis- This is a drip infusion of high doses of the drug. It is used similarly to acute tocolysis to relieve the threat of premature birth and in other emergency cases. The drug enters the blood through a dropper or through a lineomat. In some cases, before the onset of massive tocolysis, the patient may be given a single dose of Ginipral.
• Prophylactic dose may be prescribed if there is almost no threat to pregnancy. To prevent the resumption of contractions or uterine hypertonicity, the doctor may prescribe Ginipral tablets. If a woman is transferred from droppers to this form of the drug, then she should take one tablet every three hours. Gradually the dose is reduced to two tablets per day. Then the medicine is taken as needed, and the course can be quite long - up to the 35th-36th weeks of pregnancy. You should take no more than eight tablets per day.

Method of drug withdrawal

It is known that if you suddenly stop taking Ginipral, the uterus may begin to contract again, and this will negate all the results of treatment. Therefore, doctors advise reducing the dose gradually. This is carried out in several stages:

1. first, the woman is transferred from intravenous administration to taking tablets;
2. The dose of tablets is halved daily, gradually reducing the intake to nothing.

The duration of the withdrawal course is determined by the doctor individually.

How does taking Ginipral affect childbirth?

The drug may affect labor in different ways. It happens that their due date is delayed for some time (several weeks and sometimes months). It happens that the effectiveness of the drug is insufficient, then the birth process does not stop.

In cases where Ginipral is used urgently during labor, a caesarean section is usually performed if there are indications from the fetus or mother. The withdrawal period for active substances from the body is about seven days, so if labor begins a week after administration, the medicine will not have any effect on its course.

Latest update of the description by the manufacturer 30.09.2011

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Active substance:

ATX

Pharmacological groups

3D images

Composition and release form

in a PVC/Al blister. 10 pieces.; in a cardboard pack 1 or 2 blisters.

Description of the dosage form

Pills: white, round, biconvex.

pharmachologic effect

pharmachologic effect- tocolytic.

Pharmacodynamics

Relaxes the muscles of the uterus, reduces the frequency and intensity of contractions, suppresses spontaneous and oxytocin-induced labor contractions. During childbirth, it normalizes the strength and regularity of contractions, suppresses (in most cases) premature contractions and helps prolong pregnancy until the normal due date. Has little effect on the cardiovascular system of the pregnant woman and fetus.

Pharmacokinetics

When taken orally, it is well absorbed. It is excreted in the form of a dimethylated derivative in the urine and in the bile - in the form of complex metabolites.

Ginipral ® consists of 2 catecholamine groups, which in the human body undergo methylation via catecholamine-O-methyltransferase. Hexoprenaline becomes biologically inactive only if both of its catecholamine groups are methylated. When administered intrabronchially, 3 H-labeled hexoprenaline is excreted in the urine in the form of a biologically active substance for a relatively long time. Part of the injected substance remains active at the injection site for quite a long time.

Indications for the drug Ginipral ®

Threat of premature birth (as a continuation of infusion therapy).

Contraindications

hypersensitivity (especially in patients suffering from bronchial asthma and hypersensitivity to sulfites);

thyrotoxicosis;

cardiovascular diseases, especially heart rhythm disturbances occurring with tachycardia; myocarditis, mitral valve disease and aortic stenosis;

arterial hypertension;

severe liver and kidney diseases;

angle-closure glaucoma;

premature placental abruption, uterine bleeding, intrauterine infections;

pregnancy (first trimester);

lactation period.

Use during pregnancy and breastfeeding

Contraindicated in the first trimester of pregnancy. Breastfeeding should be stopped during treatment.

Side effects

Dizziness, anxiety, slight tremor of the fingers, increased sweating, tachycardia, headache, increased activity of liver enzymes.

Possible decrease in blood pressure, especially diastolic. In some cases, nausea and vomiting develop.

In rare cases - ventricular extrasystole, pain in the heart (cardialgia). These symptoms disappear quickly after stopping the drug.

Blood sugar levels increase due to the glycogenolytic effect of the drug (especially in diabetes).

Diuresis decreases at the beginning of treatment. In patients with a tendency to retain fluid in the tissues, this can lead to edema.

During treatment with Ginipral ® the intensity of intestinal motility may decrease (pay attention to the regularity of stool).

In newborns - hypoglycemia, acidosis, bronchospasm, anaphylactic shock.

Interaction

A number of drugs that lower blood pressure (β-blockers) weaken the effect of Ginipral ® or neutralize it.

Methylxanthines (for example theophylline) enhance the effect of Ginipral ®.

The effect of oral hypoglycemic agents during therapy with Ginipral ® is weakened.

General anesthesia (halothane) and adrenergic stimulants (cardiovascular and anti-asthmatic drugs) increase side effects from the cardiovascular system.

Ginipral ® is incompatible with ergot alkaloid, MAO inhibitors, tricyclic antidepressants, as well as mineralocorticoids, dihydrotachysterol and preparations containing calcium and vitamin D.

Directions for use and doses

Inside with a small amount of water.

Threat of premature birth: 1-2 hours before the end of the Ginipral ® infusion, start taking tablets at a dose of 0.5 mg (1 tablet) every 3 hours, then every 4-6 hours (4-8 tablets per day).

Overdose

Symptoms: anxiety, tremor, increased sweating, severe tachycardia, arrhythmia, headaches, cardialgia, decreased blood pressure, shortness of breath.

Treatment: the use of Ginipral ® antagonists - non-selective β-blockers that completely neutralize its effect.

special instructions

Blood pressure, pulse and cardiac activity should be under constant medical supervision.

In patients with diabetes, blood sugar levels should be monitored.

Under the influence of Ginipral ®, diuresis decreases, so you should carefully monitor symptoms reflecting fluid retention in the body (for example, swelling of the legs, difficulty breathing). This is especially important in the case of simultaneous use of corticosteroids or in cases of kidney disease.

Strict limitation of excess fluid intake is necessary.

You should limit your salt intake from food.

During tocolytic treatment, it is necessary to monitor bowel movements.

With prolonged tocolytic therapy, it is necessary to monitor the state of the fetoplacental complex. When the membranes rupture and when the cervix is ​​dilated by more than 2-3 cm, the effectiveness of tocolytic therapy is low.

If surgical intervention is necessary, the anesthesiologist should be informed about Ginipral ® therapy.

It is necessary to take into account the use of any other drugs when prescribing therapy with Ginipral ®.

Coffee and tea may increase the side effects of Ginipral ® .

You should immediately inform your doctor about contraindications or the development of side effects.

Conditions for dispensing from pharmacies

On prescription.

Storage conditions for the drug Ginipral ®

In a place protected from light, at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf life of the drug Ginipral ®

5 years.

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

ICD-10 rubric	Synonyms of diseases according to ICD-10
O34.3 Isthmic-cervical insufficiency requiring maternal medical care	Cervical cerclage
O60 Premature birth	Premature pregnancy
	Immobilization of the uterus
	Immobilization of the uterus before caesarean section
	Acute tocolysis
	Preventing premature birth
	Premature rupture of water
	Premature labor pains
	Premature contractions in the prehospital stage
	Premature birth
	Threatening premature birth
	Threat of premature birth
O62.3 Rapid labor	Acute tocolysis
O62.4 Hypertensive, uncoordinated and prolonged uterine contractions	Hypertonicity of the uterus
	Cervical spasm
O66.9 Obstructed labor, unspecified	Complicated labor
P20.9 Intrauterine hypoxia, unspecified	Acute intrauterine asphyxia
	Acute intrauterine fetal asphyxia